Hematopoiesis is blood regulatory mechanism which is characterized by a rapid and continuous turnover of blood cells. If this mechanism is disrupted and blood cells can proliferate in uncontrolled manner called, hematopoietic malignancies which is coined leukemia. Leukemia is a kind of neoplastic proliferation of granulocytes or monocytes or lymphocytes or infrequently RBCs and most common type of leukemia is chronic lymphocytic leukemia (CLL). Annually, 15,000 patients are diagnosed for CLL and 5000 deaths due to CLL are reported in United States. Although its diagnostics and therapeutic choices were limited but its treatment has been well improved and clinical selective in the last decade to protracted its remissions or cure in patients.