In the present work, Rapimelt tablet of Dolasetron Mesylate were designed to enhance the patient compliance and provide a quick onset of action. Hence the main objective of the study was to formulate rapimelt tablets of Dolasetron Mesylate to achieve a better dissolution rate and further improving the bioavailability of the drug. Rapimelt tablets were prepared by direct compression using super disintegrants like Polyplasdone XL 10, SSG, Ac-di-sol in different concentration and using Mannitol and Pearlitol as the diluents. Drug - resin complex were optimized by considering parameters such as optimization of resin concentration, optimization of swelling time, optimization of stirring time, optimization of temperature, and optimization of pH on maximum drug loading. The effects of variables were observed on maximum amount of drug loading. The various precompression parameters such as bulk density, tapped density, compressibility were evaluated. The formulated tablets were evaluated for hardness, weight variation, friability, disintegration time and in-vitro dissolution profile, taste masking. Among all the formulation S13 containing high concentration of polyplasdone XL 10 and pearlitol as the diluent was considered as the best formulation. In-vitro drug release study of S13 showed more than 90 % of the drug release within 10 minutes and was considered as the best formulation