The maternal thyroid hormones (THs) facilitate significant actions on central nervous system (CNS) during the prenatal and postnatal development and whole life(El-bakry et al., 2010; Ahmed, 2011, 2012a,b, 2013, 2014, 2015a-c, 2016a-d, 2017a-u & 2018a-c; Ahmed et al., 2010, 2013a,b, 2014, 2015a,b &2018a,b; Ahmed and Incerpi, 2013;Van Hercket al., 2013; Ahmed andEl-Gareib, 2014,Incerpi et al., 2014; Candelotti et al., 2015; De Vito et al., 2015; El-Ghareeb et al., 2016; Ahmed and El-Gareib, 2017).On the other hand, postpartum thyroid disorders(hypothyroidism) are associated with the mood disorder and postpartum depression (PPD),and vice versa (Harris, 1999; Sylven et al., 2013; Le Donne et al., 2017; Zhou et al., 2017). Several investigators reported that postpartum mood dysfunctions (PPD or severe psychosis) are the main feature of maternal psychiatric morbidity (Miller, 2002; Fergerson et al., 2002; Bloch et al., 2003; Dennis, 2004; Henshaw et al., 2004; Le Donne et al., 2012; Mento et al., 2017).During the perinatal and adulthood periods, TH deficiency (hypothyroidism) can cause the following (Miller et al., 2007; Samuels et al., 2007)