Ectoparasites such as; lice and ticks play an important role in the transmission of certain pathogens which may cause fatal diseases in cattle thus; it may cause heavy economic losses due to their usual habit of blood sucking, which adversely affects the economic production. For this research study the ectoparasites were collected from city Sukkur, Sindh, Pakistan during winter and spring season at fortnightly interval basis from different five farms settled at same side of research area. The overall mean population of cattle lice, H. tuberculastus was observed on farm or treatment that indicated with T =2 (9.75) followed by T =3 (9.62), T =1 (7.87), T =4 (7.37) and T =5 (5.37). Thus; the overall ticks; H. bispinosa population was observed in farm number 5 up to (5.40) followed by farm 2 (5.10), farm 4 (4.30), farm 3 (3.41) and the minimum population was observed in farm no. 1 (3.10), respectively. It is concluded that the maximum population of lice was observed in farm no. 2 and minimum at farm no. 5 whereas; the maximum population of ticks was observed at farm no. 5 and minimum at farm no. 1. It is further recommended that the ectoparasites may cause fatal diseases in cattle which may have negative impact on economy such infection in breast may cause reduction in production of milk and cattle may also become week so the antiparasitic; Wormec super 10ml for cattle should be used to get rid of parasites.