This paper presents a study on scientific knowledge management of Biotechnology area through analysis of scientific Biotechnology trends in Brazil, providing an overview of the science profile as well as regional development and its relation to issues of topics based on the analysis of scientific publications for the period of last 10 years. Given these promising prospects, the monitoring and searching of scientific advances and trends in this area of knowledge have become essential for searching opportunities in R&D and also for potential innovations and business opportunities, both in developed countries as well as in countries of emerging economies such as Brazil. The survey was accomplished in database Web of Science using 60 terms selected in Biotechnology area and 72,187 documents has been organized. Scientific indicators were produced using data/text mining tools. It was possible to find a greater number of scientific publications in areas such as Biochemistry & Molecular Biology and Genetics & Heredity. Results pointed out The USA as the main foreign partner-country of scientific publications followed by UK, France and Germany. It was possible to verify cooperation network with others Latin American countries.