The study examined the effects of advance organizers learning strategy on reading comprehension,spelling and vocabulary development of lower primary schools in Ile-Ife. The design used was pretest-posttest quasi experimental. A sample of thirty-nine pupils of two intact classes, drawn from two randomly selected lower primary school pupils in Ife Central Local Government Area. Pupils reading Comprehension Test was administered to the population selected and the data collected were analyses using t-test. The experimental group (Group A) had a mean of 5.59 while the control group (Group B) had a mean of 4.61, the results of the experiment led us to accept that Advance Organizers has a significant effect on reading comprehension of Lower private primary school pupils. The results of the analyses after using appropriate inferential and descriptive statistics showed us that Advance Organizers aids comprehension and facilitate good retention and also help learners connect prior knowledge with what they are about to learn, this is in line with Ausubel (1963). Hence, the study established a significant positive effect in teaching lower private pupils using advance organizers learning strategy in reading comprehension. Advance Organizers has been proved to facilitate reading comprehension, however, it is recommended that teachers should motivate and guide pupils when Advance Organizers learning strategy is to be used and also government and schools should organize workshops and seminars for teachers in other to foster positive result in the performance of pupils in reading comprehension.